|
KMID : 1144120170070020115
|
|
Biomedical Engineering Letters
2017 Volume.7 No. 2 p.115 ~ p.120
|
|
|
Biological effects of blood?brain barrier disruption using a focused ultrasound
|
|
Han Mun
Hur Yong-Ki
Hwang Ji-Eun
Park Ju-Young
|
|
|
Abstract
|
|
|
|
With focused ultrasound (FUS) and microbubbles, BBB can be transiently disrupted with a localized and non-invasive approach. BBB disruption induced by FUS has made progressions to move forward on delivery of therapeutic agents into a brain in a specific area of brain for better treatment of neurological diseases. In addition to be used as an improvement of drug delivery, BBB disruption has been found to induce biological effects such as a clearance of protein aggregation which cause Alzheimer’s disease, regulation of proteins which facilitate drug uptake, and modulation of neuronal function and neurogenesis. In this review, we discuss overview about the principles of BBB opening with FUS and milestones in these biological effects of FUS-induced BBB disruption.
|
|
|
KEYWORD
|
|
|
Focused ultrasound, Blood?brain barrier, Microbubble, Biological effects
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|